In the HeartGold & SoulSilver arc, Arceus appears as one of the main antagonists, where it plans on destroying humanity due to its mistrust of humans. It was the target of Team Rocket's plans to create Dialga, Palkia, and Giratina.
Arceus has a strong mistrust of humans and often attacks them without cause as a result. After seeing Gold bond with his Togekiss though Arceus began to regain some trust in humans.
It is a very powerful, having created Dialga, Palkia and Giratina in the Sinjoh Ruins.