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Route 224 is a narrow peninsula on the same island as Victory Road, stretching to the east. It is described as a miniature of the Sinnoh region.
At its end is a white rock which Professor Oak says, if the player has Oak's Letter, has a counterpart in the Kanto region. This unlocks the special event in which players can capture Shaymin.
A colored background means that the Pokémon can be found in this location in the specified game. A white background with a colored letter means that the Pokémon cannot be found here.
Trainers with a Vs. Seeker by their names, when alerted for a rematch using the item, may use higher-level Pokémon.
Trivia
This route has one of three movie cameos in the game. The aforementioned Easter egg is Ace TrainerRebecca, a Trainer who analyzes battles using her laptop. She challenges the player with her Metagross. However, this cameo was not recognized by translators, as English versions call her Jamie (in Japanese version her name is ヒトミHitomi, like in the movie).