The sprawling Saffron City is home to two rival Pokémon Gyms; the official Saffron Gym, and the adjacent Fighting Dojo. Situated in the middle of town is the headquarters of Silph Co., which manufactures items like Potions and Poké Balls. It is the company's top-secret development project that has drawn Team Rocket to the city.
A colored background means that the Pokémon can be found in this location in the specified game. A white background with a colored letter means that the Pokémon cannot be found here.
Visit the house in the southeast to meet Mr. Psychic, and get TM29 (Psychic) from him.
Fighting Dojo
One of Saffron's major attractions is that there are two Gyms here, not one. Located adjacent to the official Saffron Gym, the Fighting Dojo is an optional challenge. While there is no badge to be won here, the Karate Master will offer the choice of two Fighting Pokémon—the hard-kicking Hitmonlee or the piston-punching Hitmonchan.
With Pokémon Tower cleared, the guard outside Silph Co. is taking a nap, leaving a perfect opportunity to sneak inside. The company uses warp tiles to allow their employees to quickly move around the huge building, which create a giant maze leading to Giovanni.
The objective is to reach the top floor and rescue the Silph president from Giovanni. Taking the direct route to the top floor avoids most of the 31 Trainer battles here (and the money and experience that goes with it) and gets right to the boss, after which Trainers can collect the items without opposition. When medical attention becomes an issue, either leave for the Pokémon Center or look for the woman in the southwest corner of the 9th floor.
There's no way to bypass the electronic doors yet, so step on either warp to teleport to 8F.
8F
Silph Co, 8F
Clear out the Rockets here, then take the elevator to 3F.
3F
Silph Co, 3F
Step out of the elevator and take the warp near the stairs back to the second floor. Talk to the woman to get TM36 (Selfdestruct), and warp back to 3F.
Fight the lone Rocket and take the warp in the southwest to a locked room on 5F. Grab the TM09 (Take Down) and warp back. Climb the stairs to the fourth floor.
4F
Silph Co, 4F
Beat the Rockets here, and climb to the fifth floor.
5F
Silph Co, 5F
Beat the Rocket and Scientist near the stairs, and follow the hallway to the south to find a Rocket next to a warp tile. Defeat the Rocket, jump on the warp, and warp right back. Walk down and follow the narrow path to the right to find the Card Key, which opens any of the building's electronic doors. Go back towards the Rocket, and open the northwest door for a Protein. Get upstairs to 6F.
6F
Silph Co, 6F
Open the door past the Scientist to find an HP Up and an X Accuracy. Climb to 7F.
7F
Silph Co, 7F
Use the Card Key to open the nearest door and grab TM03 (Swords Dance). You can battle the grunt on the other side of the door near the TM, but the nearby warp only leads back to 5F. After battling the Rocket along the north wall (next to the counter), walk to the left you'll see your rival loitering in the next room. Follow the narrow hallway south to an area with a Scientist, grab the Calcium, and head up two flights of stairs to reach 9F.
9F
Silph Co, 9F
By now, your team may be running out of energy. After beating the Rocket, open the door nearby and talk to the woman near the beds. To thank you for your efforts, she'll heal your team to full health. Beat the second Rocket and take the stairs to 10F.
10F
Silph Co, 10F
There are only two thugs to fight here, but make sure to grab the Carbos, Rare Candy, and TM26 (Earthquake) from the southwest room. Take the stairs to 11F for a quick battle.
11F (east)
Silph Co, 11F
Beat the lone Rocket Grunt here, and take the elevator all the way down to the third floor.
3F
Use the Card Key to unlock the door in the center of the floor. Unlock the next door beyond that, beat the Scientist, grab the Hyper Potion behind him, and take the warp near the first door. This sends you up to 7F again, where your rival attacks.
One last Rocket Grunt stands before Giovanni; take out his Cubone, Drowzee, and Marowak to clear a path to the boss. If your team needs to rest, take a trip to the Pokémon Center or the woman on 9F to heal up. Open the door with the Card Key to confront Giovanni.
With Giovanni defeated, Team Rocket's hold on Silph Co. is broken. The president is so relieved that his company is saved that he rewards you with the Master Ball prototype, a version of Poké Ball that catches any Pokémon without fail!
With the Rockets gone, you are free to collect any leftover items sitting around the building; stop by the 4th floor, and check the west room for a Full Heal, Max Revive, and Escape Rope. You're also free to challenge the Saffron Gym.
Saffron Gym
Saffron Gym
SAFFRON CITY POKéMON GYM LEADER: SABRINA
The Master of Psychic Pokémon!
After the battle, Sabrina awards you the Marsh Badge. This badge ensures obedience from all Pokémon up to level 70. She also gives you TM46 (Psywave) as a gift.